Scope and Collaborations
Molecular biophysics tools may be of use to scientists or teachers
working on a variety of genes including cancer, inherited deafness
and vision loss related proteins. Shown below is an overview of
protein homology models that have been studied and refined using
both local and global optimization algorithms.
Click on the images to enhance the size.
Inherited Deafness
Shown below are a refined GJB2 Hexamer and a portion of
the GIPC3 protein. The GIPC3 structure is displayed from
residues 108 to 196. Structures of other proteins related
to inherited deafness can be found online at
https://github.com/wtollefson/dvd-structures.
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| GJB2Hexamer |
GIPC3 |
Holden Comprehensive Cancer Genes
The refining algorithms used often result in lengthening of
secondary structure in proteins and increased stability.
A small portion of the extracellular domain of Kit
is shown below with some secondary structured highlighted in boxes.
The images demonstrate an increase in secondary structure.
Structures of additional Holden Comprehensive Cancer Center
proteins can be found online at
https://github.com/rcorrigan/holden-structures.
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| Original Kit |
Refined Kit |
Inherited Vision Loss
The vision variation related proteins MAK and PAX6 are
shown below. MAK is diplayed from residue one to 284, and PAX6 is
displayed in complex with DNA. A database of the original
and refined models of vision variation proteins can be
found online at
https://github.com/avlynn/VVD-structures.
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| MAK |
PAX6 |
